Leptin supplements and weight loss

Since the discovery of leptin in 1994, many hoped that the hormone is a promising weight-loss treatment for humans. Leptin acts as a signal to help the body decide when it has eaten enough food to feel full. The amount of leptin in the blood is directly linked to body fat. then receiving leptin replacement therapy, research subjects with a recessive mutation in the obesity (ob) gene - a population both deficient in leptin and morbidly obese - lost about half of their body weight while regulating their own food intake. (Medical News Today 05/04/2005). whether you take it at face value, it seems as if the research is saying that more leptin will help you lose weight. This research refers to the subject with a genetic basis for obesity with deficient in leptin. but obese individuals tend to have more and larger leptin-producing fat cells than thinner people. They just are not getting the vital chemical signals in their brains that tell them to stop eating. to illustrate my point: despite a diligent search, scientists have found only a half dozen people in the world who make no leptin.

The people eat voraciously - one 3-year-old girl consumed 2,000 calories in one sitting. When some of these people are treated with leptin, they lose their appetites and their weight plummeted. (The New York Times 10/31/1999). don ¡¯ t get me wrong, if it helps those who can not produce leptin, then it is a major breakthrough for them. A study published in the Journal of the American Medical Association, will go a long way toward proving me more leptin is not equal less weight on very overweight people in the general population. things to do worse, a hormone called leptin that to be the magic bullet for obesity, making people effortlessly lose fat while maintaining muscle, looks like a bust. a preliminary study reported last week, most people who took little or no leptin lose weight - fat one who took the highest dose actually gained 20 pounds. (The New York Times 10/31/1999). researchers at the Harvard School of Public Health in Boston say lean, physically active people have lower levels of leptin, which is produced by the body's fat cells and is believed to be a major culprit in causing obesity. the study when couch potatoes begin exercising regularly, their leptin levels decrease.

When fatter, your body produces more leptin, ¡± says eric b. RIMM, Sc.D., associate professor of epidemiology and nutrition at Harvard School of Public Health, and a co-author of the study. ¡° But when you exercise, the amount of leptin in the blood decreases. Most of the time, you also lose weight, which means that your risk of heart disease decreases too. ¡± (science daily 03/07/2000). Normally, when leptin levels in the blood go up, the brain signals us to stop eating. But since obesity is not the result of a lack of leptin, it is a response to the lack of leptin, and obese individuals tend to have more and larger leptin-producing fat cells (leptin is a hormone secreted by of fat cells) than thinner people, their leptin levels increase substantially with every pound of additional weight gain. correct me if I'm wrong, but there appears to be no logic to the idea of getting more leptin to lose weight if you have an impaired response to leptin. it is important to keep in mind that the study showed that increasing leptin levels in people who weight it helps to keep the weight off.

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